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Very Credible
ukri.org
How cells fight infection from the inside – UKRI
Scientists have described for the first time how cells can digest bacteria and viruses from within. The study, published today in the Cell Press journal Molecular Cell, details a method of germ resistance they’ve coined ‘antibody-directed xenophagy’ (ADX).
advances.massgeneral.org
How Human Cells Fight Bacteria—and How Bacteria Fight Back - Mass General Advances in Motion
Researchers at Massachusetts General Hospital have identified <strong>SAC1, a transmembrane lipid phosphatase</strong>, as a key regulator of xenophagy-directed bacterial clearance and show that SteA, a Salmonella...
americanscientist.org
Pathogens, Host-Cell Invasion and Disease | American Scientist
The disadvantage, however, is that its proteins would be exposed at the membrane and thus would be recognized as alien structures by antibodies. Using the antibodies as markers, immune cells would sweep in and destroy the infected cell and the pathogen in it. Figure 8. Listeria monocytogenes bacteria (red) in an infected kidney epithelial cell “grow” tails made of actin (green), the protein that gives flexibility and motility to cells, as they move through the infected cell.
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sciencedirect.com
Xenophagy: Pathogen-Containing Vacuoles Are Hard to Digest - ScienceDirect
Many intracellular pathogens reside in host-membrane-encased vacuoles, but the mechanism initiating xenophagic targeting of these vacuoles was unknown. A recent study identifies the host vacuolar-ATPase as essential to xenophagic clearance and the Salmonellae effector SopF that inhibits bacterial clearance by its ADP-ribosylation.
cell.com
Xenophagy: Pathogen-Containing Vacuoles Are Hard to Digest: Current Biology
In this regard, an exciting new study from Xu et al. stands out for its biological relevance and clarity [11]. The authors noted that although there are host mechanisms in place to direct autophagic targeting and clearance of intracellular Salmonellae, in epithelial cell lines, only about 20% of intracellular S. Typhimurium are decorated with LC3 within one hour of infection [12]. This further shrinks to 5–10% two hours post-infection, indicating that there could be unknown mechanisms in place to subvert this host clearance mechanism. Using a transposon genetic screen, Xu et al. looked for b
pmc.ncbi.nlm.nih.gov
Control of Phagocytosis by Microbial Pathogens - PMC - NIH
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