77%
IsItCap Score
Truth Potential MeterGenerally Credible
Generally Credible
nih.gov
DNA organization changes in Alzheimer’s disease, aging | National Institutes of Health (NIH)
Nathan Zemke and Bing Ren of the University of California, San Diego looked at cells from the brain’s hippocampus, which is important for forming and recalling memories. They found <strong>an overall loss of 3D genome organization with age</strong>.
sciencedaily.com
Scientists find a new layer of Alzheimer’s hidden in the genome | ScienceDaily
Scientists found that the 3D organization of DNA is disrupted in several types of brain cells affected by Alzheimer’s disease, <strong>altering how important genes are switched on and off</strong>.
archynewsy.com
Scientists Discover New Genomic Layer and 3D Structural Changes in Alzheimer's - Archynewsy
According to a study published ... brain cells affected by Alzheimer’s disease, revealing <strong>a hidden layer of epigenetic dysregulation that drives cognitive decline</strong>....
ua.news
3D genome organization changes identified in Alzheimer’s disease | UA.NEWS
Researchers from Carnegie Mellon University, the University of Pittsburgh School of Medicine, Washington University and other institutions have found that the three-dimensional organization of the genome changes in certain brain cells of people with Alzheimer’s disease.
senseaboutscience.org.uk
Alzheimer's 3D genome organisation disrupted across multiple brain cell types, study in Science finds - Sense About Science Blog
The researchers are careful about this: they describe Alzheimer’s 3D genome organisation differences as ‘associated with’ changes in gene activity, and the paper frames future work around testing whether particular structural changes help drive disease progression or could eventually become targets for new therapies. A separate strand of the research involved an artificial intelligence model called Hicformer, developed to investigate how genome structure may influence cellular behaviour. The model combines DNA sequence information with broad patterns of genome folding and detailed maps of physical contacts between different sections of DNA, then uses those inputs to predict gene activity across different cell types.
frontiersin.org
Frontiers | Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by synapse dysfunction and cognitive impairment. Understanding the development and progression of AD is challenging, as the disease is highly complex and multifactorial. Both environmental and genetic factors play a role in AD pathogenesis, highlighted by observations of complex DNA modifications at the single gene level, and by new evidence that also implicates changes in genome architecture in AD patients.
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